Thank you to science reporter Carl Zimmer and the New York Times for helping to break the silence that humans are likely not born sterile (column link), as we're so often taught.
Last week, our PLOS Biology paper came out with the evidence-full position that maternal microbial transmission is far more common than previously thought in animals and that decades of research on this topic lie ahead of us. Carl picked up the phone to chat with graduate student Lisa Funkhouser (@dnadiva87) and I about the paper. What follows below is his NY Times column that came out today. I'm quite pleased with Carl's reporting here as he covered the diversity of researchers who have produced the scientific evidence thus far.
Personally, I am most impressed by the following pieces of evidence:
- Bacteria are readily found in umbilical cord blood
- Pregnant mice fed a labelled bacteria have babies with the same labelled bacteria in their meconium; controls do not
- Preterm birth is often associated with improper bacterial colonization of the gut. Now what just might be in the guts of term babies?
So moms, you not only pass on your genes and mitochondria, but likely your bacteria too. Can we thank you enough? My mom would most definitely say no.
Link to open access article and Related Blog Posts:
MATTER
Human Microbiome May Be Seeded Before Birth
By CARL ZIMMER
Published: August 29, 2013
We are each home to about 100 trillion bacteria, which we carry with us from birth till death. But when Juliette C. Madan was trained as a neonatologist in the mid-2000s, her teachers told her in no uncertain terms that we only acquire those bacteria after we are born. “It was clear as day, we were told, that fetuses were sterile,” she said.
More 'Matter' Columns
Matter: As Humans Change Landscape, Brains of Some Animals Change, Too (August 27, 2013)
Matter: Watching Bacteria Evolve, With Predictable Results (August 15, 2013)
A Family Consents to a Medical Gift, 62 Years Later (August 8, 2013)
Matter: How Simple Can Life Get? It’s Complicated (July 4, 2013)
Dr. Madan is now an assistant professor of pediatrics at the Geisel School of Medicine at Dartmouth, and she’s come to a decidedly different view on the matter. “I think that the tenet that healthy fetuses are sterile is insane,” she said.
Dr. Madan and a number of other researchers are now convinced mothers seed their fetuses with microbes during pregnancy. They argue that this early inoculation may be important to the long-term health of babies. And manipulating these fetal microbes could open up new ways to treat medical conditions ranging from pre-term labor to allergies.
In 1900, the French pediatrician Henry Tissier declared unborn babies bacteria-free. Only when they started their journey down through the birth canal did they begin to get covered with microbes. The newborns then acquired more as they were handled and nursed.
“This was considered a kind of scientific dogma,” said Esther Jiménez Quintana of Complutense University of Madrid.
This dogma gained strength from studies on babies born prematurely. Infections are a major risk factor in early labor. Many researchers saw this as evidence that the only bacteria in the uterus were dangerous ones.
But scientists came to this conclusion without finding out whether healthy fetuses had bacteria, too. “It became a self-fulfilling prophecy,” said Dr. Madan.
That has started to change in the past few years. In 2010, Josef Neu, a University of Florida pediatrician, examined the first stool from newborn babies, before they had their first meal. He found a diversity of bacteria in the stool, whether the babies were born on time or born prematurely.
“When we first saw this, we though it was an artifact,” said Dr. Neu. If the fetuses were indeed sterile, their stool should have been germ-free. But in follow-up studies, he has gotten the same results.
Other scientists have also found evidence indicating that healthy fetuses pick up bacteria in the womb. Dr. Quintana and her colleagues have found bacteria in the amniotic fluid of healthy babies, as well as in umbilical cord blood and placentas.
If other animals are any guide, we shouldn’t be surprised if human fetuses are laced with bacteria. In an essay published last week in the journal PLOS Biology, Seth R. Bordenstein and Lisa J. Funkhouser of Vanderbilt University observed that mothers transmitting bacteria to their offspring is the rule rather than the exception in the animal kingdom. Studying other species may give scientists clues about how human mothers inoculate their unborn children.
One open question is the route that bacteria take from mothers to their fetuses. A number of researchers suspect that immune cells in the mother’s intestines swallow up bacteria there and ferry them into the bloodstream, where they eventually wind up in the uterus.
It’s also not clear whether mothers deliver a random collection of species or a special set that are beneficial to them. Studies on children and adults have shown that our resident bacteria — collectively known as the microbiome — help us in many ways. They digest compounds in our food that would otherwise be indigestible.
Beneficial bacteria also help tutor the immune system, so that it attacks pathogens without overreacting and damaging the body itself. The microbiome can even fend of disease-causing bacteria.
Dr. Neu and other pediatricians are now investigating whether the microbiome helps fetuses before birth. He speculates that a healthy supply of bacteria in a fetus can reduce the chances of premature birth. If harmful bacteria manage to slip past those defenses, they may trigger an immune reaction that is sensed by the mother, prompting her to go into labor.
As scientists investigate the microbiome, they are also exploring ways of manipulating it to treat disorders ranging from gut infections to autoimmune disorders. Dr. Neu hopes it may be possible someday to bring the same medical help to fetuses.
“We might provide mothers with a microbial cocktail,” he said. The bacteria would pass from a mother to her fetus. Doctors might prescribe certain species to protect the fetus from infections, warding off early labor. Nurturing the fetal microbiome could help babies in other ways, like boosting their immune system.
Some scientists don’t think the evidence supports these ideas, though. Bacteria in fetuses may not have any special role to play in their health. “It could just be part of the vulnerabilities that pregnancy poses on the maternal body,” said Maria Dominguez-Bello, an associate professor at N.Y.U. Langone Medical Center.
But figuring out which explanation is right will demand the careful study of healthy fetuses — something that has only barely begun.
“The frontier is ahead of us,” said Dr. Bordenstein.
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